Why Study R-loops?

R-loops are RNA:DNA three-stranded hybrid structures dynamically formed in cells by base pairing. R-loops have important regulatory functions in DNA replication, epigenetic, transcription, and diseases.

Epigenetic regulation by R-loops

• DNA methylation regulation

• Chromatin remodeling

• lncRNA anchor

Transcription regulation by R-loops

• As gene promoter

• As regulator of transcription factor/repressor binding

• In transcription regulation stabilization

R-loops in human diseases

• Cancers

• Neurological disorders

• Autoimmune diseases

Learn more>>.

Fig. 1. R-loops in human diseases

How to Study R-loops?

• Epitranscriptomic Array
   [PMID: 41717060] Hualong Zhu,et al.
   (2026) Eco-Environment & Health

• tRF&tiRNA Pretreatment Kit
   [PMID: 41555020] Xu M, et al.
  (2026) Nature Biotechnology

• tRF&tiRNA Sequencing
   [PMID: 41330933]
    FJunichiro Ishikawa, et al.
   (2026) Nat Communications

• LncRNA Array
  [PMID: 41519884] Hyeon-Ji Kim,
  et al (2026) Signal Transduction and
  Targeted Therapy

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Valid 8/1/2026 - 10/31/2026